Targeting Proteins for Degradation Characterizing PROTAC Kinetics and Mode of Action...

Targeting Proteins for Degradation: Characterizing PROTAC Kinetics and Mode of Action...

Targeting Proteins for Degradation: Characterizing PROTAC Kinetics and Mode of Action Using Live-Cell Assays

Tuesday, November 13, 2018

Despite the promising potential of PROTAC compounds in new drug discovery strategies, interrogating the multiple steps required to achieve effective PROTAC-mediated target protein degradation remains a challenge. This webinar will describe a platform of live-cell assays that can be used to measure real-time degradation kinetics and key cellular protein interactions mediating the degradation process. Join us to learn how these tools can be used to improve functional and cellular characterization of your PROTAC compounds.

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 Kristin M. Riching 

Kristin Riching received her Ph.D. from the University of Wisconsin–Madison, where she studied the structural and mechanical properties of collagen fibers and their effects on breast cancer cell migration in invasive ductal carcinoma. She then worked as a postdoctoral researcher at Promega studying ligand-induced protein interactions within the ErbB signaling network and their roles in cancer progression. She has been at Promega for four years and is currently a Senior Scientist developing approaches to monitor functional mechanisms of proteasome-mediated protein degradation.